Keivan Ghodrati - Chemistry Department, Faculty of BasicScience, Islamic Azad University, Kermanshah, Iran
Azita Farokhi
Changiz Karami
Maryam Goodarzi

An efficient synthesis of 3,4 3,4-dihydropyrimidinones or thiones (DHPMs) is described, using nano silica SiO2 for the first time as the catalyst from an aldehyde β-keto ester and urea or thiourea in acetonitrile. Compared to the classical Biginelli reaction conditions, this method consistently has the advantage of excellent yields, mild reaction conditions, ease of workup, survival of different functional groups, and short reaction times.

Dihydropyrimidinones or thiones (DHPMs); nano Silica jel; Biginelli reaction; Multi component reactions (MCR)