Effects of Curcumin-Loaded Chitosan Nanoparticles on Corneal Permeation
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 523
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شناسه ملی سند علمی:
ACSOMED28_044
تاریخ نمایه سازی: 1 دی 1397
چکیده مقاله:
Purpose: Curcumin (CUR) could be a striking free radical scavenging molecule in ocular disease. In this study,the effects of Curcumin-loaded chitosan (CS) nanoparticles on corneal permeation was assessed. Methods: CS NPs was prepared by the ionic gelation method using CS and tripolyphosphate (TPP). Ex-vivo corneal permeation of CUR from CUR NPs / CUR loaded NPs were determined using modified side by side Franz diffusion cell. Results: Ex-vivo corneal permeation of CUR was higher from CUR loaded formulation increased significantly in comparison with CUR alone containing NPs and free CUR dispersion (p<0.05). Conclusion: Taken together, use of Curcumin-loaded Chitosan (CS) nanoparticles enhanced Ex-vivo corneal permeation
نویسندگان
Mehrnaz Moattari
Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran
Farahnaz Moattari
Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran
Gholamreza Kaka
Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran
Homa Mohseni Kouchesfahani
Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran