Synthesis of3-(1H-1-imidazolyl)-2-methyl-4-chromanoneas a pharmaceutical composition defaultby α-bromo-2-hydroxy acetophenone

سال انتشار: 1393
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 792

فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

AEBSCONF01_471

تاریخ نمایه سازی: 6 آبان 1393

چکیده مقاله:

The maximum range antifungal drugs are relatively limited impact, or due to toxicity, The lack of the potential for systemic use . Therefore, this study With the goal gain of antifungal With a wide And fewer drug interactions, seems to be necessary. Derivatives of 1-(2-hydroxy-phenyl)-2-(1H-1- Imidazolyl)-1-ethanol Undergo cycloaddition reaction is the whit Acetaldehyde And compound 3-(1H-1-Imidazolyl)-2-methyl-4-chromanone is prepared as azole drugs whit the potential effect of fungicide . Chemical structure built determined and confirmed By infrared spectroscopy, nuclear magnetic resonance and mass spectrometry . In order to differentiate and identify the trans Stereoisomers Between the two groups imidazole and methyl in the ring chromanone was used of the 1H NMR spectroscopy.

کلیدواژه ها:

نویسندگان

Jafar azimvand

Payam Noor University of Tehran