Synthesis 1,2-Diacetates by ZnSO4.7H2O Catalyst with Ring Opening of Epoxides with Acetic anhydride under Refluxing Conditions
محل انتشار: سومین همایش ملی کاربردهای شیمی در فناوریهای نوین
سال انتشار: 1392
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 1,231
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شناسه ملی سند علمی:
CAAT03_009
تاریخ نمایه سازی: 29 بهمن 1392
چکیده مقاله:
ABSTRACT An efficient and simple protocol for regioselective ring opening of epoxides with thiols, aceticanhydride, and alcohols using 16 wt % MoO 3 supported on alumina as a recyclable catalyst is described.Epoxides are highly versatile synthetic intermediates in organic synthesis as they undergo ring-openingreactions with various nucleophiles to afford 1,2-difunctionalized compounds. -Hydroxysulphides, 1,2-diacetates, and -alkoxyalcohols are valuable synthones and being extensively used as key inter-mediates inthe synthesis of various biologically active natural and synthetic products [1]. Among the reactionsmentioned above, direct transformation of epoxides into 1,2-diacetates is a very important, but scarcelystudied, reaction [2].ZnSO4.7H2O is inexpensive, efficient, readily available, and mild catalyst, which has surface properties, andsuggests very rich organic chemistry. Zinc sulfate is the inorganic_compound with the formula ZnSO4 aswell as any of three hydrates . It was historically known as white vitriol . It is a colorless solid that is acommon source of soluble zinc ions [3].Here, a simple and efficient method for the conversion of epoxide to1,2 - diacetate with acetic anhydride solvent under reflux conditions returned by a rapid catalyst areintroduced. The capability of this synthetic protocol was investigated by the reaction of activated,deactivated, and cyclic epoxides with anhydride acetic/ ZnSO4.7H2O system under the optimized conditions.The epoxides were converted to the corresponding 1,2-Diacetates in exellent yields within short times(Scheme 1).
کلیدواژه ها:
نویسندگان
Kamel Ahmadi lavin
Department of Chemical Engineering, Faculty of engineering, Islamic Azad University, Ahar, Iran
Ronak Eisavi
Department of Chemistry, Payame Noor Universtiy
Rasool Daryaie
Department of Chemical Engineering, Faculty of engineering, Islamic Azad University, Ahar, Iran
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