Role of Chromosome Inversion (pericentric and paracentric) in Recurrent Abortions

Recurrent abortion is a problem that affects almost 1% of women who want to conceive. More than 50% of miscarriages in the first trimester are due to chromosome abnormality. The aim of this study is to present the role of chromosomal inversions in recurrent miscarriages. One group of inversions occurring in recurrent abortions involves chromosome 9,around its centromere. A second group of inversions are those having the breakpoints near the centromere of the long andshort arm of chromosomes 2, 3 and 10. We studied 1878 patients with recurrent abortions were referred to our department during 1385-1392 for chromosome investigation. The samples were studied using high resolution GTG banding technique. For each patient, a minimum of 15 metaphaseswas examined by light microscopy. Pericentric inversion around centromere of chromosome 9 was observed in 26 patients (1.4%) and pericentric inversion in centromeric region of chromosome 1 was found in one patient (0.05%). One patient had pericentric inversion ofchromosome 2 (0.05%). Chromosomal inversion involving other autosomal chromosomes such as pericentric inversion ofchromosomes 11,5 and 12, and paracentric of chromosomes 6,7,8, and 12, were also observed (0.4%). The chromosomal imbalance of gametes may produce spontaneous abortions and malformed offsprings. This suggests that such inversions should not be ignored and they can play an important role in reproduction failure. However, we have shown that the rate of pericentric inversion of chromosome 9 is similar in different referral groups (1-2%) and similar to normal population and thus of no clinical significance

کلیدواژه ها:

Chromosome Inversion ، Recurrent Abortions ، ، inv(9)