Electrooxidation of dextromethorphan on a carbon nanotubes-carbon microparticles-ionic liquid nanocomposite

The electrooxidation of dextromethorphan on a nanocomposite constructed with carbon nanotubes-ionic liquid-carbon fine powders was investigated by cyclic voltammetry in a 100 mM phosphate buffer solution (PBS), pH 7.40. In the voltammograms, an irreversible diffusion-controlled anodic peak was appeared. The diffusion coefficient of dextromethorphan and the electron transfer coefficient and the standard rate constant of electrooxidation of this drug were found to be 3.45×10-6 cm2 s-1, 0.65 and 1.67×10-3 cm s-1, respectively. A sensitive and time-saving determination procedure was developed for the analysis of dextromethorphan, and the corresponding analytical parameters were reported. Using this method, dextromethorphan was determined with a LOD and LOQ of 8.81 and 29.36 μM in linear range of 2.5×10-4 to 3.3×10-3 M, respectively. The proposed amperometric method was successfully applied to the analysis of commercial pharmaceutical products (such as tablets, syrup and oral drop) and the results were in good agreement with the declared values.

کلیدواژه ها:

Dextromethorphan ، Ionic liquid ، Carbon nanotube ، Nanocomposite