Evaluation of Yield Strength of PLGA/nano-BCP Composite Scaffolds During In Vitro Degradation Fulltext
[ M Ebrahimian-Hosseinabadi ] - Graduate student
[ F Ashrafizadeh ] - Professor, Department of Materials Engineering, Isfahan University of Technology
[ M Etemadifar ] - Asistant Professor, Orthopedic Department, School of Medicine, Isfahan University of Medical Sciences
Nano composite scaffolds improve biocompatibility, mechanical properties and cell behavior in comparison to similar compositions in micro-scales and are more desirable for bone tissue engineering. In this paper, the yield strength of Poly (lactide-co-glycolide) (PLGA) and PLGA/nBCP (Nano-biphasic calcium phosphate) composite scaffolds, during in vitro degradation, are presented. Prepared Nano-biphasic calcium phosphate and PLGA were used as reinforcement (with 10-50 wt%) and matrix of composite scaffolds, respectively. All scaffolds, with more than 89% porosity, were fabricated by thermally induced phase separation (TIPS). Various techniques including SEM, TEM and XRD were employed to investigate the samples. During in vitro degradation (0-6 weeks) the results of yield strength indicated that PLGA/nBCP scaffolds with 30 wt% nano- BCP have the highest value of strength among the composite scaffolds.
Bone tissue engineering, Nano composite scaffold, Mechanical properties, Biphasic calciumphosphate, In vitro degradation
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