Investigating the effects of pulsed 217Hz, magnetic field on the growth and development of a transplanted fibrosarcoma tumor in Balb/c mice.

With regard to the reported biological effect of different frequencies of ELF and also the use of 217 Hz frequencies as a modulating radiofrequency waves 0f 900 MHz in Global System for Mobile, the purpose of this study become the investigation of the effect of Magnetic Field in 217Hz frequency on the growth of tomor cells. 49 male mice of Balb/c race with the age of 6 -8 weeks were randomly divided into 7 group (3 test group, 3 sham group, and control group) and in turn, 100%, 75%, and 30% at least required cells in order to cause tumor injected subcutaneously. In the second day of the after injecting of cells, test group were exposed to the homogenous field of a pair of Helmholtz coil as a daily basis 150 minutes, 7 successive day, and at the duration of 19 days. The formation of tumors was observed after 6-10 days. On the twentieth days of the experiment were anesthetized, extracted tumors. Also, tissue samples gathered in order to histological comparison. There were a significant difference (p<0/05) between test and sham group regarding size and weight of tumors. Also, there was a significant difference from the point of view of the formation of tumors. Histological comparison did not show significant difference regarding to mitosis and metastasis into other organs. But, mitosis in test group in comparison to the sham group was higher that is indicator of more active in these groups. Also, test group tumors had larger necrosis areas. This study shows that exposure to the pulse 217 Hz, 200 µT magnetic field cause to enhance the growth of fiber sarcoma tumor cells in Balb/c mice, which suggests further studies on the employment of 217 Hz modulating signal in GSM

کلیدواژه ها:

PEMF ، ELF ، GSM ، fibrosarcoma ، Balb/C