Association between adiponectin gene (rs2241426) polymorphism and male breast cancer in Ardabil City

breast cancer is considered the second most common cancer in the American woman population. Adiponectins are proteins that regulate a large number of metabolic processes including the metabolism of glucose and lipids. Reduced adiponectin levels increases the level of insulin-like growth factor and prevents cell apoptosis. The aim of this study was to determine the association of adiponectin gene (rs2241426) polymorphism with breast cancers. Methods: Our statistical population included 94 male patients with breast cancer and 83 samples as control group from Urmia City. DNA was extracted using ethanol-chloroform precipitation method. The designed complementary sequence was amplified by PCR method, and specific fragments were excised using RFLP method. Finally, data were analyzed with SPSS Ver. 22 software. Results: Based on the results, there were no significant correlations between heterozygote genotypes and breast cancer in the patients group (OR = 1.17 95%Cl = 0.61-1.49). However, significant correlations were found between dominant homozygotes and the incidence of disease (P = 0.01 95%Cl = 0.31 – 0.92 OR = 0.019). Albeit, 72% of these individuals had performed familial marriages.Conclusion: The results show that mutations in the adiponectin gene rs2241426 can only be used as a biomarker for detecting male breast cancer in dominant homozygous people with familial marriages.

کلیدواژه ها:

Adiponectin ، breast cancer ، polymorphism ، PCR