Which one is more effective in parkinson's desease? Stimulating the motor cortex or the basal ganglia?

In this paper we investigated by a computational model of the basal ganglia-thalamocortical system (BGTCS)differences between the motor cortex stimulation (MCS) and deep brain stimulation (DBS) of the subthalamic nucleus (STN) of the basal ganglia (BG) in Parkinson’s disease (PD). To this end, a mean-field model of the BGTCS is used. This model is able to reproduce both the normal and parkinsonian activities of the BG, thalamus and motor cortex in a unified structure. Using this model, we simulate DBS and MCS, and compared the effect oflocation of stimulation on mean firing rates of the BGTCS. Our results suggest that DBS of the STN and MCS could restore thalamus relay activity, but DBS effects on PD are stronger than MCS. Consequently, stimulation of cortex seems to mimic the stimulation of STN in a relatively less effective manner. Our results are compatible with the experimental and the clinical outcomes on the effects of DBS andMCS.

کلیدواژه ها:

basal ganglia thalamocortical system ، parkinson’s disease ، deep brain stimulation ، motor cortex stimulation