Synthesize and characterization of theranostic radio-MOF nanoparticles containing Cu-64 and Y-90 for treatment of metastatic bone cancer

Here MOF concept is contributed to the preparation of a novel theranostic bone-seeking agent with different sizes, composed of Cu-64, Y-90, and DOTMP for treatment of bone metastases. The products were characterized (IR, elemental analysis: CHN, ICM-MS, PIX, DLS) quality-controlled (RTLC). The stability was checked up to one week at 37ᵒC in human serum. Biodistribution studies up to 72 h were performed. Radio-MOF crystals and colloidal radio-MOF nano particles (80±20 nm) obtained by varying the synthesizing conditions (including pH and temperature), showed similar IR patterns and similar elemental analysis results. The chemical formula was [1Y-1Cu-1DOTMP] for both. The final product was synthesized at pH=8, stirring at room temperature using carrier free Y-90 and Cu-64 and DOTMP (yield > 99%, RTLC) with an average size of 80nm. The stability and in vitro hydroxyapatite binding were checked up to one week at 37ᵒC in human serum.

کلیدواژه ها:

MOF ، Cu-64 ، Y-90 ، DOTMP ، bone metastases