The Study Histopathological Changes Tissues In Dermal Toxicity of Nanosilver

Silver is a relatively rare metal that occurs naturally in the earth's crust and is released to the environment from various industrial sources. Human exposure to silver and silver compounds can occur orally, dermally, or by inhalation. Silver is found in most tissues, but has no known physiologic function. In humans, accidental or intentional ingestion of large doses of silver nitrate has produced corrosive damage of the gastrointestinal tract, abdominal pain, diarrhea, vomiting, shock, convulsions, and death [1]. Respiratory irritation was noted following acute inhalation exposure to silver or silver compounds. Silver nitrate solutions are highly irritating to the skin, mucous membranes, and eyes [2].The colloidal nanosilver solution of the present invention can be used in sanitary products, solutions for cleansing agents for clothing also be used in health care products, treating patients with all kinds of injuries and/or burns, bacterial and fungal infections, gastrointestinal bacterial infection, and sexually transmitted diseases. [3]No macroscopic changes in skin were observed, but there were histopathological changes in tissues. In control group, tissues were completely normal but there were some inflammation in other groups. As a result, the most histopathological changes were in the nanosilver concentration of 10000 ppm compared to other concentration. Thus high concentration has direct relationship with the observed changes. In this study, limitations were consisting the lack of enough nanosilver and sensitive animals.

کلیدواژه ها:

nanosilver ، dermal toxicity ، histopathological changes