Thermodynamic Investigation of DNA-Dendronized Polymer Nanocluster with Modification of Charge Distributions

The concept of gene therapy is simple-deliver exogenous, therapeutic genes to the body to treat genetic-based diseases. Many of the cationic polyelectrolyte vectors such as dendrimers [1,2] developed to date have formed nanoclusteres with DNA via electrostatic interaction. All of these polymers possess amino groups, at least a portion of which are protonated at neutral pH, to enable electrostatically driven self-assembly with DNA. The polymer can condense DNA to sizes compatible with cellular uptake while providing steric protection from nuclease degradation [3].The dendronized polymers are new class of dendimers which In the solution DNA could be wrapping around the dendronized polymer, Fig (1).The stability of this nano structure could be predicted by modelling electrostatic potentials.In the previous works [4,5] electrostatic potential and electrostatic free energies calculated for a DNA-dendronized polymer nanocluster. Here we modified the charge distribution on DNA and dendronized polymer and calculate the thermodynamic properties of this nanocluster system