Simulating the AFM-based biomanipulation of cylindrical micro/nanoparticles

As micro/nanoparticles of different shapes are placed in different biological environments, thus, it isnecessary to accurately investigate the effects of the target nanoparticle’s geometry and material as well as theimpact of the biomanipulation environment on the values of critical force and time of AFM-based manipulation.Therefore, in this article the cylindrical contact model of JKR is developed for use in the AFM-based manipulationprocess conducted within different biological environments. Then, this model is applied to simulate themanipulation of yeast nanoparticle in various environments such as air, water, alcohol and plasma. By comparingthe results obtained in this paper, it is concluded that the movement of particles in different biologicalenvironments starts later and by a force of higher magnitude relative to the air medium.

کلیدواژه ها:

AFM ، Nanomanipulation ، Different biological environments ، JKR contact model