Investigations on the Effect of Doping of Rare Earth Elements (Gd, Eu) in ZnO Nanoparticles on Improving the Efficiency of Radiation Therapy of Prostate Cancer

significant cell death using novel X-Ray sensitive Gd and Eu doped ZnO Nanoparticles (NPs) has beenreported in this paper.Preferential integration of these materials into deep-solid tumors can augment efficiency ofradiotherapy. Herein, doping of Gd and Eu into the ZnO NPs is designed to optimize restricted energy absorption froma conventional radiotherapy. Upon irradiation, energy is transferred to the Zinc Oxide crystal structure, resulting in thegeneration of reactive oxygen species (ROS). In this experiment, Gd and Eu doped and undoped ZnO NPs weresynthesized and optimized at size of 3nm. Cytotoxic effect of ZnO NPs was investigated in prostate cancer and normalfibroblast cells. Radiation enhancement by doped NPs was occurred at 20 micro.g/ml under 1.5 Gy X-Ray, which isequal with cell death of untreated cells under 6 Gy X-ray. It is worth noting that, these doped NPs can be used as aphoto inducer to increase the dose of X-rays and caused a reduction of received dose to the normal cells.

کلیدواژه ها:

Doped ZnO NPs ، Photodynamic therapy ، Radiation therapy ، Dose enhancement