Hyperthermia study using Fe0.5Zn0.5Fe2O4 nanoparticle in animal model

Magnetic nanoparticles (MNPs) are versatile tools in biomedical applications such as magnetic fluidhyperthermia (MFH). MNPs are affected from an alternating magnetic field (AMF) which leads to dissipate thermalenergy in the surrounding medium. Therefore, MNPs are used as hyperthermia agents. The goal of hyperthermia is toincrease the temperature of malignant cells up to 46°C to destroy cancer cells without any lethal effect on normaltissues.In this study, Fe0.5Zn0.5Fe2O4 nanoparticles (FNPs) were selected undergoing external magnetic field in mouse model.FNPs were synthesized via precipitation and characterized using Transmission Electron Microscopy (TEM). Afteranesthetizing and intratumoral injection of FNPs, BALB/C mice bearing implanted solid tumors located in the center ofa solenoid coil (515 kHz) for 30 min. After 24 hours mice were sacrificedand each specimen of tumors was collectedand prepared for histological analyses. Results show mean diameter of FNPs is 9 nm and is in the best size for usingin-vivo. Also, pathology results show for better treatment of tumor, higher frequency in solenoid coil was needed.

کلیدواژه ها:

Hyperthermia ، Magnetic nanoparticle ، External magnetic field ، Ferrite