Frequencies of common CYP2D6 alleles and genotypes within Isfahan population of Iran

Cytochrome P450 2D6 (CYP2D6) is an important drug metabolizing enzyme involved in the pharmacokinetic metabolism of drugs. The CYP2D6 gene is highly polymorphic and the combination of different alleles yields different phenotypes such as: extensive metabolizer (EM), intermediate metabolizer (IM) and poor metabolizer (PM). Genotyping of the important alleles in the population for assessing the efficacy of drug is of particular importance. In Iranian population, the abundance of CYP2D6 gene alleles is not well known. So in this study, the frequency of CYP2D6 *1, *2, *4, *5, *6, *10, *17 and *41 alleles as well as the frequency of different genotypes related to these alleles were studied in Isfahan province of Iran.Using TaqMan® assays common alleles of CYP2D6 were identified in 134 breast cancer patient from Isfahan province of Iran. According to our study, the frequencies of CYP2D6 *1, *2, *4, *6, *10, *17 and *41 alleles were 42.5%, 34%, 10.4%, 0.4%, 3.0%, 0.4% and 9.3% respectively. In the present study EM/EM, EM/IM, EM/PM, IM/IM and PM/PM genotypes were reported with the frequencies of 59.7%, 17.91%, 15.67%, 3.73% and 2.99%, respectively. Taken together, our findings illustrated that the frequency of PM or IM alleles and different genotypes harboring this alleles were relatively high in Iranian population. Therefore it s important to detect these patients to prevent adverse drug reactions through individualization therapy.

کلیدواژه ها:

allele ، CYP2D6 ، frequency ، genotype