The Supplementary Effect of 50,000 Units of Vitamin D in Matrnal And Infants

Vitamin D deficiency in mothers is a very important problem with maternal and fetal complications. The optimal protocol for treating vitamin D deficiency and its effects on maternal and infant outcomes is still unclear, and the issue of the safety and effectiveness of vit D supplements during pregnancy has been controversial. About dose of 50,000 units of vitamin D3, are limited in studies. Our goal this study is to review this dose in pregnant mothers and their effects. Especially in Iran, the addition of 50,000 units in addition to various studies is still a challenging topic. Results: Studies were almost done on 1018 pregnant women , which Approximately 600 of them received a dose of 50,000 units. In these studies, there was a significant relationship between increasing the high dose of vitamin D on the serum level of the mother and its effect on theinfant and reducing maternal and neonatal complications. Methods: A systematic review of some databases such as pubmed, Google scholar, and science direct regarding the key words of vitamin D in pregnancy, vitamin D deficiency in pregnancy, and clinical trials (2008-2017). Conclusion: A dose of 50,000 units of vitamin D3 in patients with low serum levels seems to be more than adequate for current pregnancy and lactating women. This dose can be considered relatively safe for mother and infant. In order to assess the role of vitamin D supplements in pregnancy, especially the dose of 50,000 units, more accurate and more random studies are required.

کلیدواژه ها:

Vit D ، Vit D deficiency ، Vit D in pregnancy ، Clinical Trial