Electrospun Nanofibrous Scaffolds Based on Chitosan for Skin Tissue Engineering

Electrospinning of chitosan solutions with polyethylene oxide (PEO) in an aqueous solution of 2 wt% acetic acid was studied. The properties of the chitosan/PEO solutions, including conductivity, surface tension and viscosity, were measured. The morphology of the electrospun mats have been investigated by scanning electron microscopy (SEM). Uniform, smooth, and ultra-fine nanofibers with diameters of ∼180–200 nm were obtained. In this study, no surfactants and co-solvents have been used. To retain mat integrity in aqueous medium, the electrospun nanofibers were stabilized. Cell attachment and proliferation on the fabricated fibrous mats showed promising results indicating the potential of the scaffolds for skin tissue engineering and wound healing applications

کلیدواژه ها:

Chitosan ، polyethylene oxide ، nanofibers ، electrospinning ، skin tissue engineering