Synthesis of chitosan-polyvinyl pyrrolidone fibrous scaffold containing calcium peroxide particles for releasing oxygen in skin engineering

Introduction Skin is one of the most important organs of the body with critical properties and roles in the human body. The skin is the first member of the body that is damaged. Therefore, it has a high recovery capacity. Any damage to it may affect the quality of human life. In general, there are two types of wounds, including chronic and acute. Chronic ulcers, like diabetic wounds, have a low recovery rate. Therefore, if the surface of the skin is damaged, the proper and effective dressing is essential for the wound healing process. Chitosan is one of the natural polymers which has been widely used for dressings due to suitable properties in the wound healing process. Despite having good properties, chitosan reveals poor mechanical properties. Moreover, in order to reduce the time of wound healing, dressings need to reduce the repair time by providing adequate oxygen at the wound surface. To reduce the time of wound healing, dressings are used to provide enough oxygen to the wound surface. Calcium peroxide(CaO2) nanoparticles have the ability to supply oxygen in the presence of water. Therefore, these nanoparticles can be used as sources of oxygen supply to the wound site. Methods In this study, we developed chitosan- polyvinyl-pyrrolidone(PVP)-calcium peroxide fibrous scaffold using electrospinning technique for wound healing process. Results Our results showed that incorporation chitosan-PVP fibrous scaffold significantly improved mechanical properties while controlled degradation rate. Moreover, nanofibrous scaffold resulted in the controlled release of oxygen at in vitro condition

کلیدواژه ها:

Wound healing ، Oxygen ، Electrospinning technique ، Chitosan