Pharmacological properties of some 3-substituted indole derivatives, a concise overview
محل انتشار: فصلنامه ارتباطات شیمی ایران، دوره: 2، شماره: 4
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 624
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شناسه ملی سند علمی:
JR_ICC-2-4_007
تاریخ نمایه سازی: 18 تیر 1394
چکیده مقاله:
Indole is a nitrogen-containing heterocycle. It is a very important motif in agriculture and pharmacy. Many compounds containing indole moiety have been isolated form nature. It is also animportant part in natural alkaloids. Tryptophan is an amino acid which posses indole. 3- Sustituted indoles are the main group of its derivatives. Because the wide-spread application of 3-substituted indolic compounds, their synthetic procedures are in demand by organic chemists. In this review, we have focused on about twenty compounds of 3-substituted indole derivativesthat showed pharmacological properties. A concise synthetic route for some of them has also been reported. The main pharmaceutical properties of these compounds are antibacterial, anticancerand antimicrobial activities.
نویسندگان
Kobra Nikoofar
Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran ۱۹۹۳۸۹۱۱۷۶, Iran
Diba Kadivar
Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran ۱۹۹۳۸۹۱۱۷۶, Iran
Samaneh Shirzadnia
Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran ۱۹۹۳۸۹۱۱۷۶, Iran