Application of N-4,4'-azodianiline(ferrocenyl Schiff base) for electrocatalytic determination of atenolol on modified carbon paste electrode

A carbon-paste electrode (CPE) chemically modified with the N-4,4'-azodianiline(ferrocenyl Schiff base) complex and multi wall carbon nanotubes (ADAFCNTE) was used as a highly sensitive electrochemical sensor for determination of trace amounts of atenolol. The oxidation peak potentials in cyclic voltammogram of ADAFCNTE occurred around 550 mV vs Ag/AgCl (at pH6.0) while this peak potential at the carbon paste electrode appeared around 800 mV at the same scan rate of 10 mV s−1. The kinetic parameters such as electron transfer coefficient, α, and rate constant for chemical reaction between atenolol and redox sites in modified electrode were 0.41 and 2.8×10^2 cm^3 mol^-1 s^-1, respectively. The catalytic peak current was linearly dependenton atenolol concentration in the range of 0.1-57.0 μmol L-1 with a detection limit of 0.08 μmol L-^1. Finally, the sensor was examined as a selective, simple and precise new electrochemical sensorfor the determination of atenolol in urine samples, with satisfactory results.

کلیدواژه ها:

Atenolol ، N-4 ، 4'-azodianiline ferrocene ، multi wall carbon nanotubes ، electrocataytic determination