Comparison of Analgesic Effects of Epidural Infusion of Fentanyl and Fentanyl-bupivacaine in Spine Surgery: A Randomized Clinical Trial Study
محل انتشار: مجله جراحی مغز و اعصاب ایران، دوره: 1، شماره: 1
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 573
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شناسه ملی سند علمی:
JR_IJN-1-1_003
تاریخ نمایه سازی: 15 شهریور 1395
چکیده مقاله:
Background & Aim: Although most patients experience severe pain after major spinal fixation surgery, little attentionhas been paid to control it with a multi-modal approach. The aim of this study is to select appropriate method of painmanagement after spinal surgery.Methods & Materials/Patients: This study was a randomized clinically controlled trial in candidates ofspondylolisthesis and spinal fixation surgery under general anesthesia. 90 patients were divided into three groups,as follows: 1) Intervention group of epidural fentanyl (F): patient-controlled analgesia (PCA) pump infused 100 μgof fentanyl and 98cc of normal saline at the rate of 3-5 ml/h in the epidural space via an epidural catheter placedby surgeon 2) Intervention group of epidural fentanyl-bupivacaine (FB): PCA pump infused 100 μg of fentanyl andbupivacaine 0.125% at the rate of 3-5 ml/h in the epidural space. 3) IV morphine group (M): No medication wasreceived epidurally. In case of visual analog scale (VAS) score more than four, one mg of IV morphine bolus wasadministered to patient. The blood pressure, heart rate, respiratory rate and pain severity were recorded at the momentof patient’s transfer from recovery room to the ward and compared in three groups every six hours for 24 hours. Theresults of this study were analyzed by statistical tests including repeated measures ANOVA, Kruskal-Wallis, Fisher’sexact test and SPSS software 16. P values less than 0.05 were considered statistically significant .Results: The results of the study showed that VAS score in fentanyl-bupivacaine group was significantly lower thanthat in the two other groups during the first 18 hours. However, VAS score in all groups decreased at 24th hourpostoperatively (less than three) suggesting that there was no statistically significant difference between the threegroups. In this study, no serious and severe complications were observed except for a few cases of nausea in the controlgroup.Conclusion: Epidural analgesia with fentanyl-bupivacaine is a safe and effective way to postoperative pain managementin listhesis and spinal surgeries.
کلیدواژه ها:
نویسندگان
Ali Ashraf
Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran
Gita Khanjanian
Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran
Shahrokh Yousefzadeh-Ghabok
Guilan Road Trauma Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran
Babak Alijani
Guilan Road Trauma Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran