Comparison of Prooxidant-antioxidant Balance between Patients with High Grade Gliomas (IV) and Control Group

Background & Aim: The most common primary brain tumors of the central nervous system are gliomas. Among anumber of different biomolecular events, a strong relation between oxidative stress pathways and the developmentof this cancer has been proved. Oxidative stress (OS) is the consequence of an imbalance between pro-oxidantsand antioxidants towards pro-oxidants. The pro-oxidants cause lipid peroxidation of cell membranes, protein, DNAoxidation and changes in brain cell growth. In this study, the pro-oxidant–antioxidant balance (PAB) was determinedin patients with gliomas.Methods & Materials/Patients: Sera of 49 patients with high grade glioma (grade IV WHO) which is calledglioblastoma multiform (GBM) and 49 healthy subjects were collected and PAB test was measured.Results: A significant increase of PAB value was observed in patients with GBM (158.10±85.71 HK unit) in comparisonto control group (74.54±33.54 HK).Conclusion: The PAB assay showed the oxidative stress in glioblastoma. In further research, this easy elucidation ofoxidative stress in these patients can be applied to evaluate the effectiveness of antioxidant therapies in patients withGBM.K

کلیدواژه ها:

Prooxidant-antioxidant ، Balance ، High Grade Gliomas