Serum and Urine Level of Zinc in Patients with Minor Beta Thalassemic in Ali-asghar Hospital During the Years 2005-2006

سال انتشار: 1386
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 587

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شناسه ملی سند علمی:

JR_IJP-2-2_002

تاریخ نمایه سازی: 5 آبان 1393

چکیده مقاله:

Introduction and Objective: Zinc as the second trace element of the human body plays an important role in numerous functions. A large number of research studies have showed serum zinc deficiency andexcess urinary excretion in patients with major beta thalassemia, but few studies revealed excess urinary zincexcretion in minor beta thalassemia and no study investigated serum zinc levels in this group. This study aimed to measure serum and urine zinc level in patients with minor beta thalassemia. Materials and Methods: The study was observational and cross-sectional. Blood and 24-hour urinesamples were collected from carriers of beta thalassemia who attended Ali Asghar Hospital for blood transfusions for their children. They had documented hemoglobin electrophoresis for their status. The serum and urine zinc levels were measured by atomic absorption spectrophotometer. Student’s t test was used forcomparison of groups. Results: The average level of zinc in the serum and urine of the male cases was 69 ± 10 μg/dl and 714 ±162 μg/dl and in the female cases was 58 ± 11 μg/dl and 751 ± 162 μg/dl respectively and was 64 ± 12 μg/dland 730 ± 120 μg/dl totally. The obtained serum zinc was lower and the urine zinc was higher in minor beta thalassemic persons than the amounts mentioned by references for the subjects of the same sex and age. Theserum zinc level of anemic patients with minor beta thalassemia was lower (63 ± 11 vs 72 ± 13 μg/dl) andthe urine zinc level was higher (792 ± 183 vs 673 ± 202 μg/dl) than non-anemic patients. Conclusion: Minor beta thalassemics have lower serum zinc level and due to abundant roles of zinc can make benefit from zinc supplementation. This decrement may be attributed to tubulopathy in these patients

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نویسندگان

Foroogh sadat Hashemi

Dept. of Pathology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

Maryam Abolhasani

Dept. of Pathology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

Seyed Mohammad Hakimi

Dept. of Infectious Diseases and Pediatrics, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Massih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences,Tehran, Iran