A Survey on Urinary Pathogens and their Antimicrobial Susceptibility among Patients with Significant Bacteriuria

سال انتشار: 1387
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 838

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شناسه ملی سند علمی:

JR_IJP-3-4_004

تاریخ نمایه سازی: 5 آبان 1393

چکیده مقاله:

Background and Objective: Urinary tract infection (UTI) is one of the most common diagnosed infectious diseases. In order to determine the spectrum of bacterial etiology and antibioticresistance pattern of the uropathogens that cause community acquired UTI, a retrospective study was performed in Research Center of Reference laboratories of Iran on urine samples of referred patients during a 4 years period (from 2002 to 2006).Materials and Methods: During the study period, 4207 urine specimens were cultured. Cultureswith a significant bacterial growth were selected and susceptibility testing was performed using diskdiffusion method. Results: Out of 4207 urine specimens, 476 (11%) yielded positive culture. Escherichia coli (44.5%) and Klebsiella pneumoniae (8.5%) were the most predominant isolated bacteria respectively. Escherichia coli revealed the highest susceptibility among oral antibiotics to nitrofurantoin (76%) and the highest rate of resistance to carbenicillin (94%) and ampicillin (89%) respectively. In totalisolates, the highest level of susceptibility was for imipenem (99%) and among oral antibiotics for nitrofurantoin (70 %), and the highest level of resistance was for carbenicillin (89%) and ampicillin (84%). Conclusion: The results of this study revealed a considerable resistance to fluoroquinolones and cotrimoxazole and a high sensitivity to nitrofurantoin among isolated bacteria. We strongly recommend nitrofurantoin as the drug of choice for empiric therapy of UTI in our country.

نویسندگان

Farinaz Rashedmarandi

Department of Bacteriology, Research Center of Reference Laboratory of Iran, Tehran, Iran

Marjan Rahnamayefarzami

Department of Bacteriology, Research Center of Reference Laboratory of Iran, Tehran, Iran

Mahnaz Saremi

Department of Bacteriology, Research Center of Reference Laboratory of Iran, Tehran, Iran

Roghayeh Sabouri

Department of Bacteriology, Research Center of Reference Laboratory of Iran, Tehran, Iran