Cervicovaginal Cytopathology by Liquiprep™ a New Liquid Based Method in Comparison with Conventional Pap Smear
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 4، شماره: 2
سال انتشار: 1388
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 661
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شناسه ملی سند علمی:
JR_IJP-4-2_001
تاریخ نمایه سازی: 5 آبان 1393
چکیده مقاله:
Background and Objective: The aim of this study was to compare the screening performance of a new modified liquid-based cytology method (Liquiprep™) with conventional PAP smear (CP) ina low risk population, using colposcopy followed by histology as gold standard . Patients and Methods: This cross-sectional study was performed on random referred specimens to a general gynecological clinic in Tehran, during 20 months by a split-sample method. In bothCP and Liquiprep™ group, all positive and 10% of negative results of smears were followed by colposcopy. A biopsy was taken whenever any atypical transformation zone seen. Sensitivity,specificity, negative and positive predictive values (PV), and overall accuracy of both methods wereanalyzed in relation to histology. Results: A total of 1265 patients were analyzed by two methods. In 158 (12.5%) of cases histologicaldiagnosis was made. Liquiprep™ samples (94.7%) were more adequate than CP (92.1%). There was not any low or high-grade squamous intraepithelial lesion (SIL). Atypical squamous cell of undetermined significance (ASC-US) was diagnosed more with CP than with Liquiprep™ (1.43%vs. 0.79%) while pathologically 60% of ASC-US in Liquiprep™ and 16.6% in CP had degrees of SIL. The Liquiprep™ had a significantly higher sensitivity (83% vs. 66%) and positive PV (83% vs. 33%) than the CP to detect SIL at histology but the difference in specificity was non significant(98% vs. 86%). Conclusions: This study confirms the superiority of the Liquiprep™ method to detect cervical lesions in a low risk population.
کلیدواژه ها:
نویسندگان
Mahmood Khaniki
Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran.
Zeynab Nazary
Dept. of Gynecology, Mazandaran University of Medical Sciences, Mazandaran, Iran
Kazem Zendehdel
Dept. of Epidemiology, Karolinska University, Stockholm, Sweden
Fereshte Fakur
Dept. of Gynecology, Gilan University of Medical Sciences, Rasht, Iran.