A Comparative Study of Atypical Squamous Cells of Undetermined Significance in Pap Smears Followed by Biopsy Results for Determination of Reliable Cytologic Parameters

Background and Objective: Microscopic evaluation of cervicovaginal smears (Pap smear) plays an essential role in detection of preneoplastic and neoplastic lesions of uterine cervix. A widespectrum of changes is seen in Pap smears. Interpretation of intermediate changes which resultingin observation of so- called ASCUS is difficult. ASCUS is defined as a cellular change that is moremarked than typical reactive change but lack features diagnostic of intraepithelial neoplasia. Theaim of this study was determination of reliable cytological parameters to identifying real nature ofASCUS. Patients and Methods: In this descriptive, cross sectional study, all Pap smears with presence of ASCUS, which followed by biopsy samples in Urmia, Shahid Matahari hospital during March 1999to December 2002 were reviewed. In this regard, 17 parameters of cytoplasm, nuclei and smearbackground were considered and data were analyzed by SPSS and Chi Square test. Results: Four parameters of irregular nuclear contour, increased nucleo- cytoplasmic ratio,cytoplasmic vacuolization and dirty background are highly suggestive of dysplasia. Conclusion: It is important to consider that to find out the real nature of ASCUS a group of parameters are more helpful than a single one. In addition, a single Pap smear is not enough for this purpose and further investigation is required.

کلیدواژه ها:

Papanicolaou test ، Cervix Dysplasia ، Cancer ، Iran