Granulosa Cell – Stromal Tumors: An Immunohistochemical Study Including Comparison of Calretinin and Inhibin

سال انتشار: 1388
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 602

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شناسه ملی سند علمی:

JR_IJP-4-4_005

تاریخ نمایه سازی: 5 آبان 1393

چکیده مقاله:

Background and Objective: Histopathological evaluation of granulosa cell tumors (GCT) of the ovary may be confused morphologically with a wide variety of the tumors. Immunohistochemicalstaining for inhibin and calretinin can be used for better diagnosis. Although it has been suggestedthat inhibin can be a sensitive marker for GCT, it maybe had negative results in some cases. In addition, caltrinin has been proposed as a marker for GCT. The aim of this study was to investigatethe immunohistochemical methods (IHC) including a comparison of calretinin and inhibin markersin the diagnosis of these tumors.Patients and Methods: This prospective study carried out from 2000 to 2009 at Ghaem and Omid hospitals, Mashad University of Medical Sciences, Iran. A total of 23 ovarian GCT specimens were immunostained with commercially available antibodies to find out calretinin and inhibinimmunoreactivity. Data were analyzed by descriptive statistical method. A P value of =<0.05 was considered significant.Results: For diagnosing GCT, the sensitivity of calretinin was 100% and that of the inhibin was almost 73.9%. The extent and severity of staining was more extensive for calretinin compared to inhibin P<0.001. Conclusion: Calretinin is a more sensitive biomarker for GCT than inhibin.

کلیدواژه ها:

Calretinin ، Inhibin ، Granulosa Cell Tumor ، Immunohistochemistry ، Sex Cord-Gonadal Stromal Tumors

نویسندگان

Zohreh Yousefi

Dept. of Obstetrics and Gynecology, Mashhad University of Medical Science.Mashhad, Iran

Nourieh Sharifi

Dept. of Pathology, Mashhad University of Medical Science, Mashhad, Iran

Farnoosh Sadatmand

Dept. of Obstetrics and Gynecology, Mashhad University of Medical Science.Mashhad, Iran

Soodabeh Shaid Salles

Dept. of Radiotherapy Oncology, Mashhad University of Medical Science, Mashhad, Iran