Hodgkin Lymphoma and Anaplastic Variants of Non-Hodgkin Lymphoma

سال انتشار: 1390
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 483

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شناسه ملی سند علمی:

JR_IJP-6-4_004

تاریخ نمایه سازی: 5 آبان 1393

چکیده مقاله:

Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologicfeatures. Since they all represent distinct clinico-pathologic entities, we explored the differentialdiagnostic impact of immunophenotyping to discriminate between them.Materials and Methods: We included 61 cases diagnosed as CHL, ALCL, and anaplastic variantof DLBCL. We reviewed morphologic microscopic findings by conventional staining and immunohistochemistry (IHC) with antibodies against PAX-5, CD30, CD15, CD45, EMA, ALK-1,and LMP-1. Results: Fifty cases corresponded to CHL (81.97%), 4 cases to ALCL (6.56%), and 4 cases toDLBCL (6.56%) excluding 3 cases, which remained unclassifiable (4.92%). PAX-5 was expressed in 94% of CHL and 100% of DLBCL cases. LMP-1 was expressed in 52% of CHL and 25% ofDLBCL cases. EMA was invariably expressed in all 4 cases of ALK+ALCL. It was expressed in4/50 cases (8%) of CHL and in 2/4 cases (50%) of DLBCL. CD45 was expressed in all cases of ALCL and DLBCL but also in 3/50 cases (6%) of CHL.Conclusion: The differentiation between ALCL and CHL based on EMA and CD45 is not reliable. Utilization of PAX-5 in combination with other markers such as CD15 and LMP-1 is recommended. CD20 and PAX-5 are not too helpful in the differentiation of CHL and DLBCL, while CD15 and CD79a were found to be quite useful discriminative markers for this purpose.

نویسندگان

Hamid Tabrizchee

Dept. of Pathology, Kerman University of Medical Sciences, Kerman, Iran

Armita Esmaili

Dept. of Pathology, Kerman University of Medical Sciences, Kerman, Iran

Sergio Cogliatti

Dept. of Pathology, State Hospital, St.Gallen, Switzerland