Serum Uric Acid Level and Metabolic Syndrome in Patients Undergoing Coronary Angiography

سال انتشار: 1391
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 663

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شناسه ملی سند علمی:

JR_IJP-7-2_004

تاریخ نمایه سازی: 5 آبان 1393

چکیده مقاله:

Background and Objectives: The association between metabolic syndrome (MetS) and hyperuricemia has been formerly studied mostly in healthy people in western countries. We triedto examine the relationship between hyperuricemia and MetS in an Iranian population undergoing coronary angiography. Materials and Methods: From March 2008 to September 2008, we studied 465 patients (260 men, 55.9%) undergoing elective coronary angiography due to symptoms related to coronary artery disease. The MetS was defined according to the adapted Adult Treatment Panel III (ATP-III A), andhyperuricemia was defined as serum uric acid concentrations ≥ 7.0 mg/dl in men and ≥ 6.0 mg/dl in women. For the statistical analysis, the statistical software SPSS version 13.0 and the statistical package SAS version 9.1 were applied Results: The mean age of the study population was 59.66 ± 10.04, ranging from 31 to 85 years. Hyperuricemia was detected in 231 (49.7%) of total population, in 126 (54.5%) of men, and in105 (45.5%) of women. In the multivariable adjusted model, subjects with MetS and subjects with 5 components of the MetS compared to those without any components of the MetS, had 1.56-fold and 4.19-fold increased odds of hyperuricemia, respectively. Hyperuricemia was significantlyassociated with elevated BP and low level of HDL-cholesterol but not with other components of MetS.Conclusions: Our study demonstrated that hyperuricemia was strongly associated with theprevalence of MetS according to adapted ATP III guidelines in an Iranian sample of patients undergoing coronary angiography.

نویسندگان

Maryam Sotoudeh Anvari

Dept. of Surgical and Clinical Pathology, Tehran Heart Center, Tehran University of Medical Sciences,Tehran, Iran

Mohammad Ali Boroumand

Dept. of Surgical and Clinical Pathology, Tehran Heart Center, Tehran University of Medical Sciences,Tehran, Iran

Mahmood Sheikhfathollahi

Dept. of Biostatistics , Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Leila Pourgholi

Dept. of Surgical and Clinical Pathology, Tehran Heart Center, Tehran University of Medical Sciences,Tehran, Iran