Searching the Human Herpes virus 6 and 7 (PCR) In CSF of Children Admitted In Pediatric Ward of Rasoul Hospital, Tehran, Iran
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 7، شماره: 2
سال انتشار: 1391
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 722
فایل این مقاله در 5 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJP-7-2_006
تاریخ نمایه سازی: 5 آبان 1393
چکیده مقاله:
Background and Objectives: Meningoencephalitis in Iranian children is frequent, but encephalitis is rare .The frequency of HHV-6 and HHV-7 in central nervous system diseases of our children is unclear. The aim of this study was searching the DNA-s of HHV-6 & HHV-7 in CSF samples of children with meningoencephalitis Materials and Methods: A cross sectional study (2007-2009) was done in Pediatric Ward in Rasoul Hospital, Tehran Iran. Totally, 150 CSF samples obtained from children (1-180 months) with meningoencephalitis. Conventional and BACTEC Ped Plus medium, latex agglutination tests were used for ruling out the bacterial causes. We searched the DNA-s of HHV-6 & HHV-6 quantitatively by Real time - PCR in 150 CSF samples obtained from children with meningoencephalitis.Results: 60.7 % of cases were male. Fever was reported (>38.5) in 74%; irritability in 70%; Convulsion was seen in 53% of cases. Herpes virus was detected in 12% (18/150) of cases. Both HHV-6 & HHV-7 were found in 6% of all cases. HHV-6 DNA was detected in 4.7% (6) and HHV-7 DNA was detected in 2 cases (1.4%) without any correlation to age, sex and clinical signs. HHV-6 was slightly more frequent than HHV-7.Conclusion: Our data indicate that herpes viruses are not uncommon causes in children with meningoencephalitis. The incidence was lower than other references.
کلیدواژه ها:
نویسندگان
Farideh Ebrahimi Taj
Dept. of Infectious Disease, Research Center of Pediatric Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran
Samileh Noorbakhsh
Dept. of Infectious Disease, Research Center of Pediatric Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran
Hamid Reza Monavari
Dept. of Virology, Research Center of Pediatric Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran
Azardokht Tabatabaei
Dept. of Microbiology, Research Center of Pediatric Infectious Diseases, Tehran University of Medical Sciences