Evaluation of Expression of EGFR, HER-2 and COX-2 in Colorectal Cancer
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 7، شماره: 3
سال انتشار: 1391
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 603
فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
این مقاله در بخشهای موضوعی زیر دسته بندی شده است:
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJP-7-3_001
تاریخ نمایه سازی: 5 آبان 1393
چکیده مقاله:
Background and Aims: EGFR and HER-2 are two members of ERbB/HER family of Type I Transmembrane growth factor receptors. Cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. The aim of this study was to determine the level of expression of EGFR, HER-2 and Cox2 in colorectd cancer.Material and Methods: IHC study was performed in paraffin-embedded blocks of 47 patients underwent colectomy due to colorectal cancer in Modarres Hospital, Tehran, Iran from 2008 to 2009. Three separated pathologists analyzed the slides after complete IHC staining for EGFR, HER-2 and COX-2.Results: EGFR, HER-2 and Cox2 revealed over expression in colorectal cancer as 80.9%, 25.5% and 72.4% respectively, EGFR revealed no statistically significant association with clinicopathologic parameters, but Cox2 overexpression exhibited statistically significant association with higher stages tumors (III, IV) (P value: 0.037) and tumor with lymph node metastasis(P= 0.005). On the other hand, HER2 overexpression showed statistically significant association with lower grade (well and moderately differentiation) tumors (P= 0.042).Conclusion: According to over expression of three markers, EGFR, HER-2, and COX-2 in colorectal cancers, using drugs that act against these receptors and investigation of survival improvement of patients with these drugs in other studies are recommended.
کلیدواژه ها:
نویسندگان
Behrang Kazeminegad
Dept. of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abbas Mirafsharieh
Dept. of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Freidoon Solhjoo
Dept. of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran