Anti-zona pellucida antibodies in infertile patients in relation to multiple puncture of ovaries and unexplained infertility
محل انتشار: مجله طب تولید مثل ایران، دوره: 4، شماره: 1
سال انتشار: 1385
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 397
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شناسه ملی سند علمی:
JR_IJRM-4-1_012
تاریخ نمایه سازی: 16 شهریور 1395
چکیده مقاله:
Background: Auto antibodies to zona-pellucida (AZA) seem to be important autoantibodies implicated in reproduction, with substantial role in both endocrine and reproductive functions of thehuman ovary. There are some debates on the relation of AZA with infertility, repeated In Vitro Fertilization (IVF) attempts, and outcome of it. Objective: In this study, we assessed the presence of AZA in the follicular fluids (FFs) of womenwho underwent intra cytoplasmic sperm injection (ICSI), in relation to etiology of infertility andmultiple puncture of ovaries. Materials and Methods: In this prospective study, follicular fluids were evaluated from 96 infertile women, (19-40 years old, 31.5±5.1), who were candidates for ICSI based on the etiology of infertility. From these 80 women had explained infertility whereas 16 had unexplained infertility. All FFs were evaluated for presence of AZA by ELISA test.Results: Twenty patients (20.8%) were positive for AZA in follicular fluid. In patients with unexplained infertility, AZA antibody in follicular fluid, was significantly higher than the group with proven etiology of infertility (p=0.001). In addition, 20.4 % of patients who had beenpunctured previously showed AZA in their FFs which is statistically similar to the patients who were punctured for the first time.Conclusions: The high incidence of AZA in infertile women, especially women with unexplainedinfertility has to be considered. Relation of the presence AZA and repeated puncture of ovaries isstill debatable. Determinations of AZA are highly recommended in evaluation of infertile couples especially in patient with unexplained infertility.
کلیدواژه ها:
نویسندگان
Soheila Arefi
Assistant Professor, Reproduction Endocrinology & Embryology Department, Avesina Research Institute, Tehran,Iran
Mahmoud Jeddi Tehrani
Associate Professor, Departement of Immunology, Avesina Research Institute, Tehran, Iran
Mohammad Mehdi Akhondi
Assistant Professor, Reproduction Endocrinology & Embryology Department, Avesina Research Institute, Tehran,Iran
Ali Reza Mousavi
Assistant Professor, Department of Social Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Science and Health Services, Tehran, Iran.