INFECTIONS AND COINFECTIONS OF HUMAN BOCAVIRUS WITH RSV AND ROTAVIRUS IN ACUTE RESPIRATORY TRACT AND GASTROINTESTINAL INFECTIONS

Background and Aim:Human bocavirus reported in the respiratory secretions of children with respiratory infection. The main objectives of the study were: to determine the relative frequency of HBoV in hospitalized children with acute gastrointestinal and acute respiratory infections; and to compare the data with those from other respiratory and gastrointestinal viral infections (RSV and Rotavirus) in the same population; and Indication of the seasonal outbreak of relative infections.Methods:This cross-sectional has done in the period 2016–2017 that involved children less than 3 years old, who were admitted to central pediatric Imam Hossein hospital in Isfahan, Iran. At first, The respiratory samples was tested for the RSV virus by direct immunofluorescence test and, the stool samples are tested for the Rotavirus virus by ELISA test and then all samples tested for the NP-1 gene of HBoV by PCR. .Results:ten out of 75 respiratory samples (13.3%) and eleven out of 75 fecal samples (14.7%) were positive for HboV. The twenty (26.7%) and twenty-five (33.3) specimens were positive for RSV and Rotavirus respectively. the 40% of respiratory samples have coinfection between HBoV and RSV (P < 0.05) and 36.4% of samples have coinfection HBoV and Rotavirus (P < 0.05). In seasonal distribution, the winter has upmost extent outbreak (P < 0.05).Conclusion:The HBoV is a major causes acute respiratory infections and coinfections of other viral causes must be investigated and explain their roles in dual infections, but in gastrointestinal infections of HBoV we need extended studies in our country and other geographical areas.

کلیدواژه ها:

human bocavirus ، Acute respiratory infections ، viral infections ، coinfections ، gastrointestinal infections