PATTERN OF STAPHYLOCOCCUS SIMULANS ANTIBACTERIAL RESISTANCE IN A REFERRAL TEACHING HOSPITAL IN NORTHEAST OF IRAN

Background and Aim:: While staphylococcus simulans is considered as the normal bacterial flora of human skin, there is some reports that it can cause severe clinical infections. Besides, there is increasing data about antibiotic and antiseptic resistance in coagulase negative staphylococci. This study was designed to investigate S.smulans antibacterial resistance pattern in a referral hospital in northeast of IranMethods:: this cross-sectional study was performed in Imam Reza referral hospital in years 2015-2016. All positive cultures for S.simulans extracted from Hospital Information System. Data were analyzed by SPSS version 24.Results:There was 3823 positive cultures. In 75 patients S.simulans was cultured from blood (39), wound (12), urine (8), eye exudates (5), pleural cavity or bronchus (5), central venous catheter (3), CSF (2), and pericardium (1). The mean age of patients was 44.8±30.1 years (range: 0.1- 93). The mortality rate was 26.7%. The most positive cultures was from emergency department (31), ICUs (8) and pediatrics department (8). Isolated bacteriae were resistant to penicillin (78%), erythromycin (78%), co-trimoxazole (54%), clindamycin (46%), cefoxitin (44%), ciprofloxacin (35%), and gentamycin (33%). All of isolates were sensitive to vancomycinConclusion:: This study shows that S.simulans has a high level of resistance to most routinely used antibacterial agents and antibiotics must be used more cautiously in our clinical practice. High positive cultures for S.simulans in some wards, especially in emergency department may be an indicator of higher contamination in those wards. More investigations about rate of sample contamination and clinical significans of S.simulans positive cultures is warranted.

کلیدواژه ها:

staphylococcus simulans ، coagulase negative staphylococci ، antibacterial resistance