A highly efficient synthesis of biologically active spirooxindole derivatives with Nano Ni as a mild catalyst under solvent-free conditions

سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 444

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شناسه ملی سند علمی:

MINMETALCONF01_054

تاریخ نمایه سازی: 25 آذر 1395

چکیده مقاله:

In this protocol, we have reported Nano Ni as an environmentally benign nature catalyst for the multi-component efficient synthesis of biologically spirooxindole derivatives, And we studied three-component, one-pot condensation of isatin/acenaphthequinone, malononitrile and different reagent including 1, 3-dicrbonyl componds, naphthol and 4- hydroxycumarin under thermal and solvent-free conditions in the presence of Nano Ni as a mild catalyst. solvent-free conditions, short reaction times, good yields, non-toxic, in expensive, simple operational procedures, one-pot, mild, easily separated from the reaction mixture with no column chomatographic sparation for the economical synthesis of these fused biologically componds are the major advantages of this literature.

نویسندگان

Farzaneh Mohamadpour

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan,Iran

Malek Taher Taher Maghsoodlou

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan,Iran

Reza Heydari

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan,Iran