Vanillic acid effects on the activity of antioxidant enzymes in billiary cirrhosis rats

Introduction: In Cirrhosis, the liver slowly deteriorates and its function is abnormal, also scar tissue replaces healthy liver tissue and the flow of blood through the liver is blocked. The Antioxidant treatments have been shown beneficial effects in liver tissue. Vanillic acid with antioxidant properties may be effective in reducing some of the complications of cirrhosis. The aim of this study was to evaluate the effect of vanillic acid on antioxidant enzyme in cirrhotic rats. Materials and methods: Four groups of eight rats were used in this study, including: control, vanillic acid (10 mg/kg, gavage, for one month), cirrhosis and receiving vanillic acid (10 mg/kg, gavage, for one month) + cirrhosis. By bile duct ligation, chronic cirrhosis was induced. The results were measured using a one way ANOVA test. P <0.05 was considered as significant. Results: A significant decrease on antioxidant enzyme (CAT, SOD and GPx) activity was observed in cirrhotic rats. A significant increase in antioxidant enzyme activity was observed in cirrhotic rats receiving vanillic acid in compared with cirrhotic group. Conclusion: Results of this study showed that vanillic acid with improved performance of antioxidant enzymes may be effective for patients with cirrhosis. © 2016

کلیدواژه ها:

Antooxidant enzyme ، Cirrhosis ، Vanillic acid ، Rat