Colorectal cancer study using biochemical mechanisms of inflammation

Introduction: According to many studies related to chronic inflammation such as viral infection parasitic as well as other factors directly and indirectly through cyclooxygenase-2 (COX-2) participate in the development of malignant diseases of the immune system. Colorectal cancer is one of the diseases known to mankind. The purpose of this paper was to review the role of inflammation in colorectal cancer and biochemical mechanism of inhibiting them. Materials and Methods: Based on studies of chronic inflammation is a known risk factor in cancer cells Apytlyal. Inflammation is defined as a cause of cancer. Inflammatory cytokines induced by increasing PG synthesis are effective. Chronic inflammations start with an increase in arachidonic acid (substrate 2-COX 2) levels. Many studies have shown that the metabolism of arachidonic acid (AA ((and the synthesis of prostaglandins (PGs), are associated with cancer progression, so that polyps in the colon tissue inflammation are activated. Results: COX-2 expression in normal tissues is very low in the colonic mucosa. But in 50% of human colorectal adenoma and carcinoma 80%, 2COX- high expression level of protein and mRNA are seen. In colorectal cancer cells, the level of mRNA 2-COX and PGG2, not in proliferative cells and differentiated cells compared with most distinctive is also the expression of a common mechanism 2COX store colorectal cancer (CRC) that is already known to induce expression of 2COX-, growth factors, cytokines, hormones, oncogenes or tumor promoters, respectively. Conclusion: The use of NSAID non steroidal anti inflammatory drugs and specific inhibitors 2 COX- used in the treatment of inflammation and many studies have been conducted in this area. We hope to discover and study new types of drugs may be promising in identifying an effective way to reduce inflammation and prevent cancer

کلیدواژه ها:

Cancer ، Cyclooxygenase ، Biochemical mechanisms ، Nonsteroidal anti inflammatory drugs (NSAID's)