Design and development Niosome Hydrogel for Topical treatment

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 534

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شناسه ملی سند علمی:

MPHBS01_123

تاریخ نمایه سازی: 22 آبان 1395

چکیده مقاله:

Introduction: Nonionic surfactant vesicles (niosomes) have drawn a lot of attention in the area of modern drug delivery systems due to their salient features such as biodegradability, biocompatibility, chemical stability, low production cost, easy storage and handling and low toxicity. Hydrogel due to better absorption can be useful in the topical treatment of skin diseases. Materials and Methods: Generally, niosomal formation requires the presence of a particular amphiphile and aqueous solvent. The association of amphiphile monomers into vesicles on hydration is the result of a high interfacial tension between water and hydrocarbon portion (or any other hydrophobic group) of the amphiphile, causing them to associate. In this study dehydration/rehydration technique is used to form niosomes and compounds, including span40, cholesterol, dicetylphosphate, PBS, carbomer and deionized water. Results: Niosomes have been used in the modern pharmaceutical industry due to their remarkable advantages over conventional vesicular delivery systems. Niosomes have the potential of being a new generation of delivery systems after the liposomes. Vesicles that were synthesized in this study were optimal in size and zeta potential and typical encapsulation efficiencies were in the range of 92.5%-93.51% for these niosomes. Conclusion: The present study has partially optimized synthesis technique for niosome as a drug carrier system and characterized its ability to encapsulate drug and leakage studies. Vesicles were formed by the combination of surfactant (Span40), cholesterol and dicetyl phosphate using appropriate setup and operating parameters. This included optimization parameters such as mass per batch, angle of evaporation, dehydration nitrogen flow rate, hydrating solvents, hydrating temperature and sonication time. Based on this success and the high efficiency of encapsulation, the objective of this research was to determine an appropriate synthesis technique for a noisome drug career system, and we observed that with this technique, dosage to treat the diseases can be decreased and deformable niosomes which are prepared using nonionic surfactants could be the future potential novel drug delivery systems for the development of enhanced transdermal delivery

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نویسندگان

Zeynab Ahmadianpour

Department of Biochemistry, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.