The Analysis of TNF-α (-308) Polymorphism in Peptic Ulcer

Tumor necrosis factor α (TNF-α) is an important mediator in inï ‚ammatory reactions andappears to play a central role in the pathogenesis of severe chronic inï ‚ammatory disease.The mechanisms which regulate the production and biological activity of TNF-α are undergenetic control and play an important role. The aim of this study was the analysis of TNF-α (-308) polymorphism in peptic ulcer. The total number of 140 subjects (70 patients with pepticulcer and 70 normal controls) was enrolled in to the study. The TNF-α -308 G>Apolymorphism was tested by PCR-RFLP. We used the Chi-square (Ï°2) test to evaluate alleleand genotype frequency among the cases and controls. The TNF-α -308 G and A allelefrequencies were 0.54 and 0.46 among cases, and 0.68 and 0.32 among controls,respectively. In cases and controles the GG genotype frequency was 30% and 47%, the GAgenotype was 49% and 41%, and AA genotype was 23% and 12%, respectively. Thepresence of the A allele lead to an increased risk for developing peptic ulcer in relation tol e a d to the control group (p= 0.0439). Our data suggest that the TNF-α -308 G>Apolymorphism can be associated with the risk of peptic.

کلیدواژه ها:

Peptic Ulcer ، TNF-α ، Polymorphism ، Tumor Necrosis Factor α ، Inï ‚ammatory