Association of Arg399Gln Polymorphism of XRCC1 Gene and Risk of Differentiated Thyroid Carcinoma in Iranian-Azeri Patients

Polymorphisms of X-ray repair cross-complementing group 1 (XRCC1) gene may influenceDNA repair capacity and contribute to individual susceptibility to different types of cancers. Inthis study, the association between XRCC1 polymorphism and increased risk ofdifferentiated thyroid carcinoma was analyzed among Iranian-Azeri patients. This casecontrolstudy was performed on 114 differentiated thyroid carcinoma patients and 91 normalcontrol subjects. Single nucleotide polymorphism (SNPs) of Arg399Gln of XRCC1 gene wasgenotyped by polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP).In the present study, Arg 399 Gln genotype (p<0.001, OR= 0.184, CI=0.09-0.372),there was a positive association for Arg 399 Arg (p<0.001, OR= 3.304, CI=1.624-6.780) andGln 399 Gln (p< 0.001, OR= 14.143, CI=1.861-296.277) genotypes with differentiated thyroidcarcinoma. The frequency of variant 399Gln allele among the cases was slightly higher thanthat in controls (P=0.269, OR= 0.798, CI=0.535-1.190). Based on these results, the XRCC1Arg399Gln genotype could be used as a useful molecular biomarker to predict geneticsusceptibility for differentiated thyroid carcinoma in Iranian-Azeri patients.

کلیدواژه ها:

Polymorphism ، XRCC1 ، Thyroid ، Carcinoma ، Iranian-Azeri