Comparison Of Inflammatory Factors In Patients With Oral Lichen Planus And Quamous-Cell Carcinoma (SCC) Of The OralCavity

Lichen planus (LP) is a relatively common chronic skin-mucous membrane disease that affects theoral mucous. Etiology and pathogenesis of the disease are not well identified. Some evidencesuggests that the immune system may play a role in the lichen planus formation and progress. Onthe other hand it is likely to convert to SCC of the oral cavity. This survey was carried out with theaim of exploring serum levels of CRP, IL1 α, IL6, and TNF α in oral lichen planus and SCC of the oralcavity.In this cross-sectional study, 25 patients with lichen planus and 25 patients with oral SCCwere chosen, as well as 25 healthy individuals, as the control group. IL1 α, TNF α, IL6, and CRP weremeasured in serum and in order to compare the means one-way variance analysis and SPSS version16 were applied (α = 0.05).According to one-way variance analysis, the mean level of IL6, TNF, andCRP in a group of patients with lichen planus were 37.23 ng/ml, 26.5 pg/ml, and 41.16 ml/dlrespectively, in addition to the group of patients with SCC of the oral cavity they were respectively49.53 ng/ml, 10.64 pg/ml, and 48.35 ml/dl and in the control group they were 39.37, 33.29 ng/ml and9.7 pg/ml. IL6 and CRP means were higher in the carcinoma group than the other two groups, on theother hand, CRP in oral lichen planus group was significantly higher the normal group, however;the value of IL1 α mean was not significantly different among various groups. According to theresults, although IL6 and CRP serum levels increase in patients with SCC of the oral cavity and IL6and TNF α levels rise in patients with lichen planus, there was no meaningful difference in IL1 αlevel of the two mentioned groups in comparison to the control group.