Role or monoclonal antibody and abc transporters in cancer

CSCs are responsible for high rate of recurrence and Chemoresistance of different types of cancer. The expression of ATP-binding Cassette (ABC) transporters family and the activation of different signalingpathways .For example( Wnt/β-catenin signaling ,Hedgehog,Notch,Akt/PKB) are reported .Considering ABC transporters expression on CSCs membranes compounds able to modulate MDR could induce cytotoxicity in these cells disclosing an exciting and alternative strategy for targeting in tumor therapy .Targeting CSCs could be a strategy to improve the outcome of cancer therapy but this is not as simple as it seems. Target such as CD۱۳۳ and EPCAM/ESA could mark out CSCs from normal cells. Monoclonal antibodies are clinically and commercially established therapeutics. This review aims to examine the biology of cancer Stemcells considering the markers defining them and their survival and will describe the new antibody-focused strategies emerging to target them for more effective treatment of cancer

کلیدواژه ها:

Cancer Symptoms ، Cell and Cancer ، Cancer Stem Cells ، Stem Cells and Cancer ، Drugs and Cancer