Silica-Bonded N-Propyl Diethylenetriamine Sulfamic Acid as a Recyclable Solid Acid Catalyst for the Synthesis of spirooxindoles

A simple and efficient one-pot three-component synthesis of the biologically important spirooxindoles scaffold was carried out by the reaction of isatin, malononitrie, and 5,5-bis-substituted-1,3-cyclohexanedione in the presence of silica-bonded N-Propyl diethylenetriamine sulfamic acid (SPDTSA) in aqueous medium. The catalyst could be recycled several times without loss in activity

کلیدواژه ها:

Spirooxindoles ، Three-component ، Water ، Isatin