Computational study of Folat- conjugated gold nanoclusters and 4amino thiophenol linker for cancer treatment with nanotechnology applications

Cancer is a disease that humans have been involved with, and scientists have done great efforts to treat it.But they have not had much success, On the other hand Nano science as a new scientific in variousbranches of science have been made many changes.Hence can be used to treat cancer of Nano science.Currently, cancer treatment is such that drugs used are not selectivity. The cancer cells are not specificallyidentified, It destroys healthy tissue and cause harm to the human body. So if we can reduce drug dose ofthe drug to the targeted tissue must be, we have partially solved the problem. With earlier studies,researchers in the field of folate and gold nanoclustres have done, Specified in the detection anddestruction of cancer cells are highly effective and very promising future.The gold nanoclustres were usedbecause it have unique properties such as adsorption of heat for the destruction of cancer cells and is alsowell connected to the folate. the 4-aminothiophenol (4Atp) is one of the best linker for binding folate andgold nano clusters. In this study we used computational method for computing stability of complex(folateand nano clusters) and geometrical and physicochemical properties.

کلیدواژه ها:

4amino thiophenol ، Anti-cancerdrug ، DFT ، folate ، gold nanocluster