Anticancer activities of cell surface targeting peptides

سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 453

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شناسه ملی سند علمی:

NEWCONF02_087

تاریخ نمایه سازی: 12 تیر 1395

چکیده مقاله:

Antitumor monoclonal antibodies have shown clinical promise as cancer cell surfacetargeting agents. The aims of this study was to evaluate the conformational study of thesome cell surface targeting peptide which can be used in multiple myeloma treatment. Theconformational structure of the 6-mer peptide of YIHYIF in different forms has beeninvestigated by the PCILO method. The computational results revealed that the peptidewhich blocked it’s C-terminal and with free N-terminal has better functionality group forbind to M- protein. Thus conformational studies shown that H3N+-YIHYIF-NHMe can beused as cancer cell surface targeting peptide in multiple myeloma.

نویسندگان

Abdollah Ramzani Ghara

Department of Plant Biology, Faculty of Sciences, University of Jiroft, Jiroft,Kerman, Iran

Fereshteh ezzatighadi

Department of Plant Biology, Faculty of Sciences, University of Jiroft, Jiroft,Kerman, Iran