Effects of CB1 antagonist rimonabant on passive avoidance memory in harmaline induced tremor

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 388

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شناسه ملی سند علمی:

NGCMED10_059

تاریخ نمایه سازی: 16 تیر 1397

چکیده مقاله:

Introduction: Genetic causes in essential tremor may include autosomal dominant mutations and also newmutations. In addition to movement complications, there are some association between ET and increased risk forcognitive impairment and dementia, which suggests that cognitive impairments in ET patients may be aconsequence of an additional neurodegenerative disorder. The endocannabinoid system is involved in cognitionand in some study showed that genetic deletion of cannabinoid type 1 (CB1) receptors accelerates age-relatedcognitive decline in rodents. In this study we aimed to test the effects of CB1antagonists on passive avoidancememory in harmaline induced rat model of tremor.Methods: Male rats (weighing 40-60 g) were kept in individual cages with access to food and water ad-libitumin a 12/12 dark/light cycle. All procedures were approved by the Kerman Medical University Ethics Committee(EC/KNRC). The animals divided in 4 group including control saline, Harmaline 10 mg/kg, Rimonabant 1 and 5mg/kg IP. Animals were placed in the light arena of the shuttle-box and the door opened and allowed to go to thedark sector. Finally, the door was closed without electric shock. The third time the animal entered the darksector, an electric shock was administered to the animal (0.5A, 5ms). In the retention trials, 24 h after training,the test was performed to evaluate memory; in this step the animal was placed in the light arena of the shuttleboxapparatus. After 30 s, the door opened and the time required to enter the dark sector was recorded asretention time (step-through latency (STL)). Time in dark compartment (TDC) was recorded as indicator ofcontextual memory.Results: Harmaline group showed significant decreased in step though latency. Time spent in dark compartmentalso was significantly increased. Number of shock in learning period was not significant different in all groups.Step through latency in harmaline and rimonabant was significantly different to control group.Conclusion: The result of this study showed that antagonizing of CB1 receptor in tremor induced by harmalinethat mimicked essential tremor can worsen the symptom and revealed possible linkage of endocannabinoidsystem with this disease.

کلیدواژه ها:

نویسندگان

Z Ghaneh

Faculty of medicine, University of medical science, Mashhad, Iran

Aghaei

Faculty of medicine, University of medical science, Mashhad, Iran

M Shabani

Kerman Neuroscience research center, Kerman, Iran- Faculty of medicine, University of Guilan, Rasht, Iran

H Abbasian

Faculty of medicine, University of medical science, Mashhad, Iran