Vitamin D status in children with cerebral palsy: A systematic review

Cerebral palsy (CP) has been defined as a disorder affecting body movement, motor skills and postural control. Itseems that Children with CP are vulnerable to developing vitamin D deficiency.so this study aimed tosystematically evaluate the Vitamin D status in children with CP.The databases of PubMed, Scopus, GoogleScholar, SID and Magiran were searched with keywords of cerebral palsy , spastic palsy, hypotonic palsy , Vitamin D , children to identify relevant articles. Included were all Persian and English observational studies,published between 2000 and December 2017.Four of 460 articles met the inclusion criteria. One of which (Finbråten, 2015) Revealed Children with CP whowere non-walkers had lower mean Bone Mineral Density (BMD) than walkers. Mean of 25 hydroxy vitamin D(calcidiol or 25OHD) concentration was lower in walkers (mean=41 nmol/L) than in non-walkers (mean=53nmol/L, p=0.041). Henderson (1996) showed, prevalence of low (< 10 ng/mL) levels of calcidiol innoninstitutionalized children with CP was significant (19%), In contrast, less than 2% of them were found tohave a low (< 20 pg/mL) level of Calcitriol (1,25-dihydroxy vitamin D) and the mean was comparable to normalpediatric subjects. Seth et al., (2017) found that median (IQR) serum 25OHD levels in patients with CP were35.6 nmol/L compared with 60 nmol/L in controls (p = 0.04) also Sixty percent of children with CP and 36.7% ofcontrols were vitamin D-deficient 25OHD < 50 nmol/L and finally Tosun et al., (2016) Revealed that Low BMDrate in CP group was 39.5 %, Abnormal BMD values were significantly related to inadequate dietary Ca intake(p = 0.017), severe intellectual disability (p < 0.001), and immobility (p = 0.018). In multivariate regressionanalysis, the risk of abnormal BMD was higher (3.9-fold) in patients not able to walk independently than theothers (p = 0.029).

کلیدواژه ها:

Vitamin D ، 25-Hydroxy Vitamin D ، Cholecalciferol ، Cerebral Palsy ، Children