PUMC Zinc/Calcium Phosphate Coating of Nickel–tungsten Amorphous Nanocomposites. Coating Procedure and Release of Nickel in Human Cell Cultures

Nickel–tungsten amorphous nanocomposites (NiW-ANC) were coated with zinc/calcium phosphate by dipping in oversaturated zinc/calcium phosphate solution. The layer thickness (typically 1–15 mm) can be varied by choice of the immersion time. The porous nature of the layer of microcrystals makes it mechanically stable enough to withstand strong bending of the material. This layer may improve the biocompatibility of NiW-ANC, particularly for osteosynthetic devices by creating a more physiological surface and by restricting a potential nickel release. The adherence of human leukocytes (peripheral blood mononuclear cells and polymorphonuclear neutrophil granulocytes) and platelets to the zinc/calcium phosphate layer was analyzed in vitro. In comparison to non-coated NiW-ANC, leukocytes and platelets showed a significantly increased adhesion to the coated NiW-ANC.

کلیدواژه ها:

NiW-ANC ، Metallic implants ، Zinc/Calcium phosphates ، Coating